Dr. Divya Patel received her Master’s in Microbiology and Ph.D. in Biochemistry from The Maharaja Sayajirao University of Baroda, Baroda, India. She then moved to USA to pursue postdoctoral research at Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL where her work focused on generating RNA Aptamers against immunotherapeutically important target molecules belonging to the tumor necrosis factor (TNF) receptor super family. Dr. Patel is currently continuing her postdoctoral training at Clark Atlanta University’s Center for Cancer Research and Therapeutic Development (CCRTD) and her research concentrates on exploring the role of members of bHLH family of transcription factors in prostate cancer development and progression.
My research focusses on human medicine with the goal of identifying key disease (specifically cancer) mechanisms and targets. With this aim, my current research work concentrates on exploring the role of members of bHLH family of transcription factors, specifically E2A (TCF3) in prostate cancer development and progression. E2A is known to regulate transcription of target genes by homo- or heterodimerization with other bHLH proteins such as MyoD, Mash, NeuroD and Id family of helix loop helix proteins. In general, E2A promotes cell differentiation, acts as a negative regulator of cell proliferation in normal cells and cancer cell lines and is required for normal B-cell development. Given the diverse biological pathways regulated/ influenced by E2A little is known about its expression in prostate cancer.
1. Patel D, Chaudhary J. bHLH transcription factor E2A is differentially regulated in Prostate cancer (In Preparation).
2. Patel D, Morton D J, Carey J, Chaudhary J. Inhibitor of Differentiation 4 (Id4) in Cancer: Tumor Suppressor or Tumor Promoter? (Submitted)
3. Patel D, Knowell A E, Yeboah M K, Sharma P, Joshi J, Glymph S, Nagappan P, Palaniappan R, Bowen N J, Chaudhary J. ID4 inactivation promotes de novo steroidogenesis and castration resistant prostate cancer. (Submitted)
4. Knowell A E, Patel D, Morton D J, Sharma P, Glymph S, Chaudhary J (2013) Id4 Dependent Acetylation Restores mutant-p53 transcriptional activity. Mol Cancer. 12 (161)
5. Sharma P, Knowell A E, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, Havrda M C, Chaudhary J(2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 12 (67)
6. Sharma P, Chinaranagari S, Patel D, Carey J, Chaudhary J (2012) Epigenetic inactivation of Inhibitor of differentiation 4 (Id4) correlates with prostate cancer. Cancer Medicine. 1(2): 176-186
7. Sharma P, Patel D, Chaudhary J (2012) Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B. Cancer Medicine. 1(2): 187-197 Sharma P and Patel D contributed equally to this work.
8. Patel D, Chaudhary J (2012) Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis. Biochem Biophys Res Commun. 422 (1): 146-151
9. Patel DK, Murawala P, Archana G, Naresh Kumar G (2011) Repression of mineral phosphate solubilizing phenotype in the presence of weak organic acids in plant growth promoting fluorescent pseudomonads. Bioresour Technol. 102: 3055-3061
10. Patel D, Archana G, Naresh Kumar G (2008) Variation in the nature of organic acid secretion and mineral phosphate solubilization by Citrobacter sp. DHRSS in the presence of different sugars. Curr Microbiol. 56: 168–174
11. Patel DK, Archana G, Naresh Kumar G (2008) Pseudomonas aeruginosa strain M3 16S ribosomal RNA gene, partial sequence. NCBI Nucleotide Databank Accession No EU711277 3
12. Patel DK, Archana G, Naresh Kumar G (2008) Pseudomonas aeruginosa strain SP1 16S ribosomal RNA gene, partial sequence. NCBI Nucleotide Databank Accession No EU711278
13. Patel DK, Archana G, Naresh Kumar G (2006) Citrobacter sp. DHRSS 16S ribosomal RNA gene, partial sequence. NCBI Nucleotide Databank Accession No DQ486057
14. Patel D, Chaudhary S , Chaudhari PM, Lahiri, Vyas D, Naresh Kumar G, Archana G (2003) Nature of organic acids secreted on various carbon sources in relation to rock phosphate solubilization by rhizobacteria. In: Proceedings of 6th International PGPR workshop, Kozhikode (Calicut), Kerala, India. pp 127-132
15. Patel DK, Parmar S, Darpalli KD, Joshi FR, Naresh Kumar G, Archana G (2002) Repression of mineral phosphate solubilising (mps) phenotype in the presence of organic acids in Pseudomonas fluorescens P4. In: Proceedings of the National symposium on Mineral Phosphate Solubilisation-2002, Dharwad, Karnataka, India. pp 186-190