Dr. Jacek Z. Kubiak received his Master degree in Plant Cytology from Warsaw University in Poland in 1983, and his PhD in Embryology from the same University in 1988, followed by postdoctoral fellowship at Institute Jacques Monod, Paris, France in 1989-1992. Since 1992, Dr. Jacek Kubiak is a full-time researcher at the CNRS, France and pursuit his career in this institution. Since 2016 he heads the laboratory of Regenerative Medicine and Cell Biology at the Military Institute of Hygiene and Epidemiology (WIHE) in Warsaw, Poland. His scientific activity focuses on the regulation of the cell cycle, embryo development and cell differentiation. He is interested in developmental potential of Mesenchymal Stem Cells (MSC) of different origin, cell cycle regulation in stem cells and early embryos and in mechanisms governing cell differentiation both in MSC and upon gonads differentiation when a binary decision is taken to differentiate into an ovary or testis in the mouse and Xenopus laevis. He is a co-editor of the series “Results & Problems in Cell Differentiation” in Springer Verlag, Heidelberg, Germany.


Area of Interest

Mesenchymal Stem Cells
Early embryo development (mouse and Xenopus)
Cell Cycle
Kinases (CDK1, Aurora, MELK)
Cancer Research
Cell and gene therapy

top publication

1. Kloc M, Kubiak JZ, Li XC, Ghobrial RM. (2016). Noncanonical intercellular communication in immune response. World Journal of Inmmunology 6(1): 67-74.
2. Kloc M, Kubiak JZ, Ghobrial RM. (2016). Are morpholino technology dilemmes an affidavit of the non-translational structural role of mRNA? Trends in Dev. Biol. 79 (9) 11-16.
3. Piprek RP, Kloc M, Kubiak JZ. (2016). Early Development of Gonads – Origin and Differentiation of the Somatic Cells of the Genital Ridges. Results Probl Cell Differ. 58, 1-22.
4. Kloc M, Liu Y, Kubiak JZ, C. Li XC, Ghobrial RM (2016) Fighting chronic rejection of transplanted organs. Atlas of Science 12 April 2016: http://atlasofscience.org/fighting-chronic-rejection-of-transplanted-organs/
5. Kloc, M, Kubiak JZ, Bilinski S. Gametic synapses, nanotubes and sperm RNAs – redefining the origin of maternal determinants: Mech. of Dev. 141, 1-3.
6. Debowski M., El Dika M., Malejczyk J., Zdanowski R., Prigent C., Tassan J.-P., Kloc M., Lachowicz M., Kubiak J.Z. (2016). Flexibility vs. robustness in cell cycle control: mathematical model of interplay between CDK1, PP2A and CDC25 in regulation of timing of M-phase entry in Xenopus laevis embryo cell-free extract. Intl. J. Dev. Biol. 60: 305 - 314.
7. Kubiak J.Z. & Prigent C. (2016). Aurora-A: an expedition to the pole of the spindle in Xenopus egg extracts. Intl. J. Dev. Biol. 60: 255 - 261.
8. Liu Y., Chen W., Minze L.J, Kubiak J.Z., Li X.C., Ghobrial R.M., Kloc M. (2016). Dissonant response of M0/M2 and M1 bone marrow derived macrophages to RhoA pathway interference. Cell. Tissue Res. 366(3):707-720.
9. Liu Y, Chen W, Wu C, Minze LJ, Kubiak JZ, Li XC, Ghobrial RM, Kloc M. (2016). Macrophage/monocyte-specific deletion of RhoA down-regulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts. J. Heart and Lung Transpl. S1053-2498(16)30292-3.
10. Borsuk E., Jachowicz J., Kloc M., Tassan J.-P., Kubiak J.Z. (2016). Role of Cdc6 during oogenesis and early embryo development in mouse and Xenopus laevis. Results Probl Cell Differ. [in press].
11. Tassan J.-P., Wühr M., Hatte G., Kubiak J.Z. (2016). Asymmetric cell division, cell-size and furrowing in the Xenopus laevis embryo. Results Probl Cell Differ. [in press].
12. Kloc M, Kubiak JZ. (2016). Structural mRNA. Encyclopedia of Signaling Molecules, 2nd Edition, edited by Sangdun Choi [in press].
13. Kloc M, Bilinski S, Kubiak JZ. (2016). Cytoskeleton and cytoskeleton-bound RNA visualization in frog and insect oocytes. Methods Mol Biol. 1457:179-90.
14. Kubiak JZ. (2016). Cell-free extracts in Development and Cancer Research for over 40 years. Int. J. Dev. Biol. 60: 189 - 191.
15. Kubiak JZ. & Kishimoto T. (2016). MPF, starfish oocyte and cell-free extract in the background - an interview with Takeo Kishimoto. Int. J. Dev. Biol. 60: 193 - 200.
16. Kubiak JZ, Cup M, Janiec J. & Kloc M. (2017). Cyclin B. Encyclopedia of Signaling Molecules, 2nd Edition, edited by Sangdun Choi [in press].
17. Borsuk E, Waksmundzka M, Szczepańska K, Ajduk A, Maleszewski M, Suwińska A, Humięcka M, Bożyk K, Szpila M, Czołowska R, Rogulska T, Ożdżeński W, Modliński JA, Kubiak JZ, Ciemerych MA. (2017). In Memoriam - Prof. Andrzej Krzysztof Tarkowski (1933-2016). Int J Dev Biol. 2017;61(1-2):1-3. doi:10.1387/ijdb.160422mm.
18. Kloc M, Kubiak JZ, Li XC, Ghobrial RM. (2015). Pericytes, microvasular dysfunction and chronic rejection. Transplantation 99(4): 658-67.
19. Liu Y, Zhang L, Tejpal N, Kubiak JZ, Ghobrial RM, Li XC, Kloc M. (2015). TCTP Silencing in Ovarian Cancer Cells Results in Actin Cytoskeleton Remodeling and Motility Increase. Journal of Analytical Oncology 4, 122-131.
20. Kubiak JZ, Chartrain I, Tassan JP. (2014). The Xenopus embryo as a model system to study asymmetric furrowing in vertebrate epithelial cells. In: Kloc L & Kubiak JZ, eds. Xenopus Development. Wiley, pp. 103-111.
21. Piprek RP, Kubiak JZ. (2014). Gonad development and sex determination in Xenopus. In: Kloc L & Kubiak JZ eds. Xenopus Development. Wiley, pp. 199-214.
22. Kloc M, Kubiak JZ, Li XC, Ghobrial RM. (2014). The newly found functions of MTOC in immunological response. J Leukoc Biol. 95(3):417-30.
23. El Dika M, Laskowska-Kaszub K, Koryto M, Dudka D, Prigent C, Tassan JP, Kloc M, Polanski Z, Borsuk E, Kubiak JZ. (2014). CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition. Dev Biol. 396 (1):67-80.
24. Kubiak JZ, Kloc M. (2014). Developmental Herpetology - state of the art of amphibian and reptile developmental biology. Int. J. Dev. Biol. 58: 719 – 721.
25. El Dika M, Dudka D, Prigent C, Tassan JP, Kloc M & Kubiak JZ. (2014). Control of timing of embryonic M-phase entry and exit is differentially sensitive to CDK1 and PP2A balance. Intl. J. Dev. Biol. 58: 767-774.