Guo-Min Deng

Director and Professor


Guo-Min Deng obtained MD degree in China and Ph.D degree in Sweden. During 2001-2006, Dr. Deng worked as research fellow in Dr Lenardo’s Lab in NIAID, NIH, USA. During 2006-2014, he worked as Instructor and Assistant Professor in Harvard Medical School, Harvard University. Since September of 2012, Dr. Deng worked as distinguished professor in Nanjing Medical University, China.


Area of Interest

1) Pathogenesis and treatment of autoimmune diseases
2) Pathogenesis of bacterial DNA-induced inflammatory disease.

top publication

1. Deng GM*, Tsokos GC. Pathogenesis and targeted treatment of skin injury in systemic lupus erythematosus. Nature Reviews Rheumatology. 2015. In press. *corresponding author

2. Deng GM*, Beltran J, Chen C, Terhorst C, Tsokos GC. T cell CD3ζ deficiency enables multiorgan tissue inflammation. J Immunol. 2013;191(7):3563-7. *corresponding author

3. Deng GM*, Liu L, Tsokos GC*. Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice. Arthritis Rheum. 2010;62(8):2424-31. *corresponding author

4. Deng GM*, Liu L, Kyttaris VC, Tsokos GC*. Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway. J Immunol. 2010;184(12):7154-61. *corresponding author

5. Deng GM*, Liu L, Bahjat FR, Pine PR, Tsokos GC*. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010;62(7):2086-92. *corresponding author

6. Shi T, Moulton VR, Lapchak PH, Deng GM, Dalle Lucca JJ, Tsokos GC. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2009; 296(2):G339-47.

7. Deng GM*. The role of bacterial DNA in inflammatory and allergic disease. Recent Pat Inflamm Allergy Drug Discov. 2008;2(2):117-22. Review. *corresponding author

8. Deng GM*, Tsokos GC*. Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. J Immunol. 2008 ;181(6):4019-26. *corresponding author

9. Deng GM*. Tumor necrosis factor receptor pre-ligand assembly domain is an important therapeutic target in inflammatory arthritis. BioDrugs. 2007;21(1):23-9. Review. *corresponding author

10. Deng GM, Zheng L, Chan FK, Lenardo M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med. 2005;11(10):1066-72.

11. Liu ZQ, Deng GM, Foster S, Tarkowski A. Staphylococcal peptidoglycans induce arthritis. Arthritis Res. 2001;3(6):375-80.

12. Deng GM*, Liu ZQ, Tarkowski A. Intracisternally localized bacterial DNA containing CpG motifs induces meningitis. J Immunol. 2001;167(8):4616-26. *corresponding author

13. Deng GM*, Tarkowski A. Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA. Arthritis Res. 2001;3(1):48-53. *corresponding author
14. Deng GM*, Verdrengh M, Liu ZQ, Tarkowski A. The major role of macrophages and their product tumor necrosis factor alpha in the induction of arthritis triggered by bacterial DNA containing CpG motifs. Arthritis Rheum. 2000;43(10):2283-9. *corresponding author

15. Deng GM, Tarkowski A. The role of bacterial DNA in septic arthritis. Int J Mol Med. 2000;6(1):29-33. Review. *corresponding author

16. Deng GM*, Tarkowski A. The features of arthritis induced by CpG motifs in bacterial DNA. Arthritis Rheum. 2000;43(2):356-64. *corresponding author

17. Deng GM*, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med. 1999;5(6):702-5. *corresponding author

18. Zhu J, Nennesmo I, Deng GM, Levi M, Wahren B, Diab A, Mix E, Zhou JN, Ljunggren HG. Induction of experimental autoimmune neuritis in CD4-8-C57BL/6J mice. J Neuroimmunol. 1999;94(1-2):196-203.

19. Zhu J, Deng GM, Diab A, Zwingenberger K, Bakhiet M, Link H. Thalidomide prolongs experimental autoimmune neuritis in Lewis rats. Scand J Immunol. 1998;48(4):397-402.

20. Diab A, Michael L, Wahren B, Deng GM, Björk J, Hedlund G, Zhu J. Linomide suppresses acute experimental autoimmune encephalomyelitis in Lewis rats by counter-acting the imbalance of pro-inflammatory versus anti-inflammatory cytokines. J Neuroimmunol. 1998;85(2):146-54.

21. Zou LP, Zhu J, Deng GM, Levi M, Wahren B, Diab A, Hillert J, Link H. Treatment with P2 protein peptide 57-81 by nasal route is effective in Lewis rat experimental autoimmune neuritis. J Neuroimmunol. 1998;85(2):137-45.

22. Zhu J, Deng GM, Levi M, Wahren B, Diab A, van der Meide PH, Link H. Prevention of experimental autoimmune neuritis by nasal administration of P2 protein peptide 57-81. J Neuropathol Exp Neurol. 1998;57(3):291-301.